Research progress of biopolymers combined with stem cells in the repair of intrauterine adhesions

Abstract Asherman syndrome (AS) refers to the loss of endometrial stem cells and matrix hyperplasia caused by basal layer injury. Its common clinical manifestations include narrowing uterine cavity, reduction in menstrual volume, abdominal pain, amenorrhea, infertility. According cause AS, treatment includes a mechanical barrier functional recovery. Because recovery endometrium depends on regeneration epithelial cells, absence cell involvement, effect repair removal adhesions is limited. Recently, tissue engineering therapy have achieved promising progress organ function. Biological scaffolds been applied encapsulated as therapeutic strategy for repairing damage. This review explains intrauterine materials combined biopolymers study AS emphasizes evidence from animal trials.